ea0063gp5 | Adrenal and Neuroendocrine - Tumour | ECE2019
Mohr Hermine
, Gulde Sebastian
, de Martino Daniela
, Richter Susan
, Pellegata Natalia
Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors derived from chromaffin cells of the adrenal medulla and paraganglia of the autonomic nervous system, respectively. Despite a common origin, these tumors are quite heterogeneous in terms of driver mutations, copy number alterations and activated downstream-signaling pathways. Genome wide expression analysis has identified at least three main tumor clusters: a pseudo-hypoxic cluster, one with activation ...